Ramage A G
Academic Department of Pharmacology, Royal Free Hospital Medical School, Hampstead, London, United Kingdom.
Naunyn Schmiedebergs Arch Pharmacol. 1988 Dec;338(6):601-7. doi: 10.1007/BF00165623.
Thoracic preganglionic sympathetic nerve activity, blood pressure, heart rate and femoral arterial conductance were recorded in anaesthetised, paralysed cats. Cumulative dose response curves were constructed for the 5-HT2 antagonists cinanserin, ritanserin, cyproheptadine, methiothepin, metergoline and ICI 169,369. These antagonists showed differing effects on the above parameters. Methiothepin and cyproheptadine caused hypotension and sympathoinhibition at low and high doses, whilst metergoline and ritanserin caused these effects at high doses, above 1 mg kg-1. Cinanserin and ICI 169,369 did cause large transient changes in heart rate, blood pressure and sympathetic outflow. However, all the antagonists except ICI 169,369 and methiothepin caused an increase in femoral arterial conductance which was not associated with hypotension. It was therefore concluded that using the above antagonists it was difficult to attribute changes in blood pressure and central sympathetic outflow to blockade of 5-HT2 receptors. However, it is suggested that 5-HT2 receptors may be involved in the control of skeletal muscle and/or skin vascular beds.
在麻醉、麻痹的猫身上记录胸段节前交感神经活动、血压、心率和股动脉传导率。构建了5-羟色胺2（5-HT2）拮抗剂辛那色林、利坦色林、赛庚啶、甲硫噻嗪、麦角苄酯和ICI 169,369的累积剂量反应曲线。这些拮抗剂对上述参数表现出不同的作用。甲硫噻嗪和赛庚啶在低剂量和高剂量时引起低血压和交感神经抑制，而麦角苄酯和利坦色林在剂量高于1 mg kg-1时引起这些作用。辛那色林和ICI 169,369确实引起了心率、血压和交感神经输出的大幅短暂变化。然而，除ICI 169,369和甲硫噻嗪外，所有拮抗剂均引起股动脉传导率增加，且与低血压无关。因此得出结论，使用上述拮抗剂很难将血压和中枢交感神经输出的变化归因于5-HT2受体的阻断。然而，有人提出5-HT2受体可能参与骨骼肌和/或皮肤血管床的控制。
