Wang Xiaoyan, Jiang Bing, Lv Huanhuan, Liang Yan, Ma Xiaofeng
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University Hangzhou 311402, China.
College of Life Sciences, University of Chinese Academy of Sciences No. 19A Yuquan Road, Beijing 100049, China.
Am J Transl Res. 2019 Aug 15;11(8):5096-5104. eCollection 2019.
Breast cancer is one of the most common cancers and the second leading cause of cancer mortality in women worldwide. Novel therapies and chemo-therapeutic drugs are still in urgent need to be developed for the treatment of breast cancer. One of the most important metabolic hallmarks of breast cancer cells is enhanced lipogenesis. Increasing evidences suggest that fatty acid synthase (FAS) plays an important role in the development of human breast cancer, for the expression of FAS is significantly higher in breast cancer cells than in normal cells. In addition, FAS inhibitors, such as curcumin, ursolic acid, and resveratrol, have shown anti-cancer potential. In the present study, we discovered that vitisin B, a natural stilbene isolated from the seeds of Pall. var. chinensis (Fisch.), was a novel FAS inhibitor. We found that vitisin B could down-regulate FAS expression and inhibit intracellular FAS activity in MDA-MB-231 cells. Also, we reported for the first time that vitisin B exhibited apoptotic effect on human breast cancer cells. Given all of this, we proposed a hypothesis that vitisin B has an application potential in the chemoprevention and treatment of breast cancer.
乳腺癌是最常见的癌症之一，也是全球女性癌症死亡的第二大主要原因。仍迫切需要开发新的疗法和化疗药物来治疗乳腺癌。乳腺癌细胞最重要的代谢特征之一是脂肪生成增强。越来越多的证据表明，脂肪酸合酶（FAS）在人类乳腺癌的发展中起重要作用，因为FAS在乳腺癌细胞中的表达明显高于正常细胞。此外，FAS抑制剂，如姜黄素、熊果酸和白藜芦醇，已显示出抗癌潜力。在本研究中，我们发现从蛇葡萄（Pall. var. chinensis (Fisch.)）种子中分离出的天然芪类化合物葡萄素B是一种新型FAS抑制剂。我们发现葡萄素B可下调MDA-MB-231细胞中FAS的表达并抑制细胞内FAS活性。此外，我们首次报道葡萄素B对人乳腺癌细胞具有凋亡作用。鉴于此，我们提出一个假设，即葡萄素B在乳腺癌的化学预防和治疗中具有应用潜力。
