Walking the tightrope: UCH-L1 as an mTOR inhibitor and B-cell oncogene.
作者信息
Bedekovics Tibor, Hussain Sajjad, Galardy Paul J
机构信息
Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA; Division of Pediatric Hematology-Oncology, Mayo Clinic, Rochester, MN, USA.
出版信息
Oncotarget. 2019 Aug 27;10(50):5124-5125. doi: 10.18632/oncotarget.27154.
Abstract
摘要
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本文引用的文献
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UCH-L1 bypasses mTOR to promote protein biosynthesis and is required for MYC-driven lymphomagenesis in mice.UCH-L1 通过绕过 mTOR 促进蛋白质生物合成，并且是小鼠中 MYC 驱动的淋巴瘤发生所必需的。
Blood. 2018 Dec 13;132(24):2564-2574. doi: 10.1182/blood-2018-05-848515. Epub 2018 Sep 26.
2
UCH-L1 is induced in germinal center B cells and identifies patients with aggressive germinal center diffuse large B-cell lymphoma.泛素羧基末端水解酶L1（UCH-L1）在生发中心B细胞中被诱导表达，并可用于识别侵袭性生发中心弥漫性大B细胞淋巴瘤患者。
Blood. 2016 Mar 24;127(12):1564-74. doi: 10.1182/blood-2015-07-656678. Epub 2015 Dec 23.
3
Ubiquitin hydrolase UCH-L1 destabilizes mTOR complex 1 by antagonizing DDB1-CUL4-mediated ubiquitination of raptor.泛素水解酶 UCH-L1 通过拮抗 DDB1-CUL4 介导的 Raptor 泛素化来破坏 mTOR 复合物 1。
Mol Cell Biol. 2013 Mar;33(6):1188-97. doi: 10.1128/MCB.01389-12. Epub 2013 Jan 7.
4
The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling.去泛素化酶 UCH-L1 是一种致癌基因，通过调节 PHLPP1 和 Akt 信号通路来驱动体内淋巴瘤的发展。
Leukemia. 2010 Sep;24(9):1641-55. doi: 10.1038/leu.2010.138. Epub 2010 Jun 24.
5
Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells.基于活性的病毒感染和恶性人类细胞泛素特异性蛋白酶（USP）分析
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6
Isolation of PGP 9.5, a new human neurone-specific protein detected by high-resolution two-dimensional electrophoresis.PGP 9.5的分离，PGP 9.5是一种通过高分辨率二维电泳检测到的新型人类神经元特异性蛋白质。
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