Woudenberg F, Slangen J L
Netherlands Institute for Drugs and Doping Research, Faculty of Pharmacy University of Utrecht.
Pharmacol Biochem Behav. 1988 Oct;31(2):375-80. doi: 10.1016/0091-3057(88)90361-9.
Rats (N = 14) were trained to respond under a five seconds differential reinforcement of low rate (DRL 5'') schedule and under a fixed ratio 10 (FR10) schedule of reinforcement. Ro 15-1788 did not influence the number of responses in the DRL 5'' schedule, but increased responding in the FR10 schedule. Ethanol (ETOH, 1250 mg/kg) and CGS 8216 (5 mg/kg) suppressed responding in both schedules and these effects were not antagonized by Ro 15-1788. The response suppressing effects of ETOH in both schedules were not influenced by CGS 8216. These results indicate that the response suppressing effects of ETOH and CGS 8216 are not mediated by the BDZ receptor. Ro 15-4513 suppressed responding strongly in the FR10 schedule. The response suppressing effects of Ro 15-4513 were additive with the response suppressing effects of ETOH. In rats (N = 11) trained to respond under a variable interval 40 seconds-fixed ratio 10 (VI 40''-FR10) schedule Ro 15-4513 dose-dependently suppressed responding. These results indicate that Ro 15-4513 has sedative effects and is not able to antagonize all the behavioral actions of ETOH.
选用14只大鼠，训练它们在5秒低率差异强化（DRL 5''）程序和固定比率10（FR10）强化程序下做出反应。Ro 15 - 1788不影响DRL 5''程序中的反应次数，但增加了FR10程序中的反应。乙醇（ETOH，1250 mg/kg）和CGS 8216（5 mg/kg）抑制了两种程序中的反应，且这些效应未被Ro 15 - 1788拮抗。CGS 8216不影响ETOH在两种程序中的反应抑制作用。这些结果表明，ETOH和CGS 8216的反应抑制作用不是由苯二氮䓬受体介导的。Ro 15 - 4513在FR10程序中强烈抑制反应。Ro 15 - 4513的反应抑制作用与ETOH的反应抑制作用具有相加性。在训练于可变间隔40秒 - 固定比率10（VI 40'' - FR10）程序下做出反应的11只大鼠中，Ro 15 - 4513剂量依赖性地抑制反应。这些结果表明，Ro 15 - 4513具有镇静作用，且不能拮抗ETOH的所有行为效应。
