Hiltunen A J, Järbe T U
Department of Clinical Psychology, University of Uppsala, Sweden.
Alcohol. 1988 May-Jun;5(3):203-7. doi: 10.1016/0741-8329(88)90053-5.
Female rats, trained to discriminate between IP administered 1.2 g/kg ethanol (ETOH) and the saline vehicle (12 ml/kg), did not press the nondrug associated lever in tests with ETOH (0.9 and 1.2 g/kg) plus the purported amethystic imidazo benzodiazepine Ro 15-4513 (3 and 10 mg/kg) as examined at two intervals after ETOH administrations viz. 7.5 and 15 min. The two doses of Ro 15-4513 were administered 5 min prior to ETOH. Response times were increased in tests with the combination. ETOH in expired air was not different in the two drug conditions, i.e., ETOH singly and together with Ro 15-4513, irrespective of the dose combinations examined. Rats trained to press a bar (FR-10 operant behavior) for sweetened water disclosed increases in the time used to obtain the reinforcer after treatments with ETOH and Ro 15-4513. Thus, Ro 15-4513 did not seem to reverse any of the behaviors examined in this study.
将雌性大鼠训练至能够区分腹腔注射1.2 g/kg乙醇（ETOH）和生理盐水载体（12 ml/kg），在分别于乙醇给药后7.5分钟和15分钟这两个时间间隔进行的测试中，用乙醇（0.9和1.2 g/kg）加所谓的抗宿醉咪唑并苯二氮䓬Ro 15 - 4513（3和10 mg/kg）进行测试时，大鼠未按压与非药物相关的杠杆。Ro 15 - 4513的两个剂量均在乙醇给药前5分钟给予。在联合用药的测试中反应时间增加。在两种药物条件下，即单独使用乙醇以及乙醇与Ro 15 - 4513联合使用时，呼出气体中的乙醇含量并无差异，无论所检测的剂量组合如何。训练为通过按压杠杆（固定比率10操作行为）获取糖水的大鼠在用乙醇和Ro 15 - 4513处理后，获取强化物所用时间增加。因此，Ro 15 - 4513似乎并未逆转本研究中所检测的任何行为。
