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水下加迷宫作为研究鱼类焦虑样行为的一种实验方法。

The submerged plus maze as an assay for studying anxiety-like behaviour in fish.

作者信息

Hope Brittany V, Hamilton Trevor J, Hurd Peter L

机构信息

Neuroscience and Mental Health Institute, University of Alberta, 4-120 Katz Group Centre, Edmonton, AB T6G 2E1, Canada.

Department of Psychology, Room 6-329, City Centre Campus, MacEwan University, 10700 - 104 Ave., Edmonton, AB T5T 4S2, Canada.

出版信息

MethodsX. 2019 Jul 8;6:1832-1837. doi: 10.1016/j.mex.2019.07.002. eCollection 2019.

Abstract

The elevated plus maze is a commonly used and well-validated test of anxiety-related behaviour in rodents. The use of fish in behavioural neuroscience paradigms is increasing, necessitating an equivalent test for studying anxiety-like behaviour in fish. Because behaviour in the elevated plus maze is driven by aversion to open space, the submerged plus maze described here uses transparent walls to elicit similar behaviour in fish. The tendency of fish to explore or avoid the sections of the maze containing transparent walls is used as proxy for anxiety level. This submerged plus maze was designed and validated for convict cichlid () fish.

摘要

高架十字迷宫是一种常用于啮齿动物焦虑相关行为且经过充分验证的测试。行为神经科学范式中鱼类的使用正在增加,因此需要一种等效的测试来研究鱼类的焦虑样行为。由于高架十字迷宫中的行为是由对开放空间的厌恶驱动的,这里描述的水下十字迷宫使用透明壁来引发鱼类的类似行为。鱼类探索或避开包含透明壁的迷宫部分的倾向被用作焦虑水平的替代指标。这种水下十字迷宫是为 convict cichlid()鱼设计并验证的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f6/6722279/24e9f15fa041/fx1.jpg

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