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探索聚糖构象与相互作用的新型核磁共振途径

Novel NMR Avenues to Explore the Conformation and Interactions of Glycans.

作者信息

Valverde Pablo, Quintana Jon I, Santos Jose I, Ardá Ana, Jiménez-Barbero Jesús

机构信息

CIC bioGUNE, Bizkaia Technology Park, Building 800, 48160 Derio, Bizkaia, Spain.

SGIker UPV/EHU, Centro Joxe Mari Korta, Tolosa Hiribidea 72, 20018 Donostia, Spain.

出版信息

ACS Omega. 2019 Aug 19;4(9):13618-13630. doi: 10.1021/acsomega.9b01901. eCollection 2019 Aug 27.

DOI:10.1021/acsomega.9b01901
PMID:31497679
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6714940/
Abstract

This perspective article is focused on the presentation of the latest advances in NMR methods and applications that are behind the exciting achievements in the understanding of glycan receptors in molecular recognition events. Different NMR-based methodologies are discussed along with their applications to scrutinize the conformation and dynamics of glycans as well as their interactions with protein receptors.

摘要

这篇观点文章聚焦于核磁共振（NMR）方法与应用的最新进展，这些进展是在分子识别事件中理解聚糖受体方面取得令人兴奋成果的背后原因。文章讨论了不同的基于NMR的方法及其在研究聚糖的构象和动力学以及它们与蛋白质受体相互作用方面的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f304/6714940/b91b3048769b/ao9b01901_0009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f304/6714940/58b0ce11dd37/ao9b01901_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f304/6714940/da9dfe67b737/ao9b01901_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f304/6714940/e482bc22d70e/ao9b01901_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f304/6714940/708713ed3299/ao9b01901_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f304/6714940/de1f788bda81/ao9b01901_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f304/6714940/b91b3048769b/ao9b01901_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f304/6714940/aeb8c63d4414/ao9b01901_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f304/6714940/4189925b10e3/ao9b01901_0002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f304/6714940/da9dfe67b737/ao9b01901_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f304/6714940/e482bc22d70e/ao9b01901_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f304/6714940/708713ed3299/ao9b01901_0007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f304/6714940/b91b3048769b/ao9b01901_0009.jpg

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