钛催化的1,2-二烯交叉环镁化反应在天然产乙酸原素-查特奈三烯素-1的全顺式立体选择性合成中的应用
Ti-Catalyzed Cross-Cyclomagnesiation of 1,2-Dienes in the Total ,,-Stereoselective Synthesis of Natural Acetogenin-Chatenaytrienin-1.
作者信息
D'yakonov Vladimir A, Tuktarova Regina A, Dzhemilev Usein M
机构信息
Laboratory of Catalytic Synthesis, Institute of Petrochemistry and Catalysis of RAS (IPC RAS), 141 Prospect Octyabrya, 450075 Ufa, Russian Federation.
出版信息
ACS Omega. 2019 Aug 16;4(9):14085-14091. doi: 10.1021/acsomega.9b01951. eCollection 2019 Aug 27.
The first total synthesis of natural acetogenin, chatenaytrienin-1, was performed in 10 steps and in 41% overall yield using cross-cyclomagnesiation of (6)-heptadeca-1,2,6-triene and trideca-11,12-dien-1-ol tetrahydropyran acetal with EtMgBr in the presence of Mg metal and the CpTiCl catalyst (10 mol %) as the key step of the synthesis.
天然产乙酸原素查特奈三烯素-1的首次全合成是通过(6)-十七碳-1,2,6-三烯与十三碳-11,12-二烯-1-醇四氢吡喃缩醛在镁金属和CpTiCl催化剂（10摩尔%）存在下与EtMgBr进行交叉环镁化反应，以10步完成，总产率为41%，该反应是合成的关键步骤。
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