Ma Chengyao, Wang Qiwen, Shi Yeye, Li Yue, Wang Xunan, Li Xiang, Chen Yong, Chen Jianwei
a Pharmaceutical Institute , Nanjing University of Chinese Medicine , Nanjing , P.R. China.
Nat Prod Res. 2017 Sep;31(18):2085-2090. doi: 10.1080/14786419.2016.1274897. Epub 2017 Jan 9.
Two new annonaceous acetogenins squamocin P (2) and annosquatin III (3) and one new ACG precursor dieporeticenin B (1) along with five known precursors (4-8) were isolated from the seeds of Annona squamosa. Their structures were ascertained by chemical methods and various spectral evidences. These compounds showed inhibitory effects against three multidrug-resistant (MDR) cancer cell lines. Compound 2 and 3 displayed selective cytotoxicity against SMMC 7721/T (IC 0.435 and 1.79 μM) and MCF-7/ADR (IC values 3.34 and 4.04 μM).
从番荔枝种子中分离出两种新的番荔枝乙酰精宁——鳞精宁P（2）和番荔枝鳞精三（3），以及一种新的乙酰精宁前体——二氢番荔枝宁B（1），同时还分离出了五种已知的前体（4 - 8）。通过化学方法和各种光谱证据确定了它们的结构。这些化合物对三种多药耐药（MDR）癌细胞系显示出抑制作用。化合物2和3对SMMC 7721/T（IC值分别为0.435和1.79 μM）和MCF - 7/ADR（IC值分别为3.34和4.04 μM）表现出选择性细胞毒性。
