Yuan Fang, Wei Fenghua, Huang Haiting, Xue Yi, Guo Pengwei, You Yanwu
Department of Nephrology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
Affiliated Hospital of Youjiang Medical University for Nationalities, Outpatients, Baise, China.
Arch Rheumatol. 2018 Aug 16;34(2):157-165. doi: 10.5606/ArchRheumatol.2019.6981. eCollection 2019 Jun.
This study aims to investigate the positive detection rate and predictive value of autoantibodies, including anti-double stranded deoxyribonucleic acid (anti-dsDNA) antibodies, anti-histone antibodies (AHAs), anti-ribosomal (anti-Rib) P antibodies, anti-Smith (anti-Sm) antibodies, anti-U1 ribonucleoprotein (anti-U1RNP) antibodies, anti-Sjögren's syndrome type A antibodies and anti-Sjögren's syndrome type B antibodies, on organ damage in patients with systemic lupus erythematous (SLE).
A total of 225 patients with SLE (37 males, 188 females; mean age 37.4±15.9 years; range, 7 to 80 years) were evaluated retrospectively. Statistical analysis was performed to obtain the positive detection rate of autoantibodies and to investigate the predictive value.
There were statistically significant differences of positive anti-dsDNA antibodies in renal damage, photosensitization, hematological abnormalities and serositis (p<0.05) and a statistically significant difference of positive AHAs in photosensitization (p<0.05). There was statistically significant difference of positive anti-U1RNP antibodies in renal damage (p<0.05). There were also statistically significant differences of positive anti-Smith antibodies in renal damage, arthritis, photosensitization, oral ulcers, hematological abnormalities and serositis (p<0.05) and of positive anti-Rib antibodies in renal damage, arthritis, photosensitization, malar rash, hematological abnormalities and serositis (p<0.05). However, there were no statistically significant differences of positive anti-Sjögren's syndrome type B antibodies and anti-Sjögren's syndrome type A antibodies in renal damage, arthritis, malar rash, neuropsychiatric disorders, hematological abnormalities and serositis (p>0.05).
Autoantibody spectrum is an important serological basis for SLE diagnosis. There are differences in the autoantibodies distribution of SLE patients with different organ damage, suggesting a certain clinical value for prediction of organ damage in SLE.
本研究旨在调查自身抗体，包括抗双链脱氧核糖核酸（抗dsDNA）抗体、抗组蛋白抗体（AHA）、抗核糖体（抗Rib）P抗体、抗史密斯（抗Sm）抗体、抗U1核糖核蛋白（抗U1RNP）抗体、抗干燥综合征A抗体和抗干燥综合征B抗体，对系统性红斑狼疮（SLE）患者器官损伤的阳性检出率及预测价值。
回顾性评估225例SLE患者（男性37例，女性188例；平均年龄37.4±15.9岁；范围7至80岁）。进行统计分析以获得自身抗体的阳性检出率并研究预测价值。
抗dsDNA抗体阳性在肾脏损害、光敏反应、血液学异常和浆膜炎方面存在统计学显著差异（p<0.05），AHA阳性在光敏反应方面存在统计学显著差异（p<0.05）。抗U1RNP抗体阳性在肾脏损害方面存在统计学显著差异（p<0.05）。抗史密斯抗体阳性在肾脏损害、关节炎、光敏反应、口腔溃疡、血液学异常和浆膜炎方面也存在统计学显著差异（p<0.05），抗Rib抗体阳性在肾脏损害、关节炎、光敏反应、蝶形红斑、血液学异常和浆膜炎方面存在统计学显著差异（p<0.05）。然而，抗干燥综合征B抗体和抗干燥综合征A抗体阳性在肾脏损害、关节炎、蝶形红斑、神经精神障碍、血液学异常和浆膜炎方面无统计学显著差异（p>0.05）。
自身抗体谱是SLE诊断的重要血清学依据。不同器官损害的SLE患者自身抗体分布存在差异，提示其对SLE患者器官损害的预测具有一定临床价值。
