Institute of Biochemistry, Saarland University, Saarbrücken, Germany.
Process and Systems Engineering Center (PROSYS), Department of Chemical and Biochemical Engineering, Technical University of Denmark, Kgs. Lyngby, Denmark.
Analyst. 2019 Oct 7;144(19):5677-5681. doi: 10.1039/c9an01246j. Epub 2019 Sep 9.
Herein, we introduce an original strategy toward one-step encapsulation, storage and controlled release of low molecular weight organic compounds via electroplated nanoparticles. This concept is demonstrated on the basis of the encapsulation of several organic matrices typically used for matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) as a case study via co-deposition with palladium nanoparticles (Pd-NPs). Remarkably, Pd-NPs act as a capsule for MALDI matrices and thus provide their controlled release depending on the external factors, viz. applied laser fluence or pH of the surrounding media. The proposed approach is considered as a simple, fast and inexpensive preparation method towards the formation of ultimate self-assembled hybrid MALDI matrices with a less pronounced "sweet spot" phenomenon and improved long-term stability.
在此，我们介绍了一种通过电镀纳米粒子一步封装、储存和控制释放低分子量有机化合物的原始策略。该概念基于几种通常用于基质辅助激光解吸电离质谱（MALDI-MS）的有机基质的封装，作为一个案例研究，通过与钯纳米粒子（Pd-NPs）共沉积来实现。值得注意的是，Pd-NPs 可以作为 MALDI 基质的胶囊，因此可以根据外部因素（例如，施加的激光强度或周围介质的 pH 值）来控制其释放。该方法被认为是一种简单、快速且廉价的制备方法，可用于形成具有不那么明显的“甜蜜点”现象和提高长期稳定性的最终自组装混合 MALDI 基质。
