Ciobanu V, Popescu D, Bălună R, Belascu I, Barac D, Tarnavschi R, Caralicea M
Medical Clinic, Grivitza Hospital, Second Department of Immunology, Bucharest.
Med Interne. 1988 Oct-Dec;26(4):267-71.
The level of plasma fibronectin (Fn) was studied in 40 patients with connective tissue diseases. Fn concentration was found increased in patients with rheumatoid arthritis (mean +/- SE, 560 +/- 30 micrograms/ml, p less than 0.01) decreased in patients with mixed connective tissue disease (337 +/- 12 micrograms/ml, p less than 0.05) and was not significantly different from controls in systemic lupus erythematosus, scleroderma, polymyositis. The value of plasma Fn level was found increased in active diseases and decreased in the cases, with presence of cryoprecipitates. The factors which might influence the level of plasma Fn and the possibility of using the changes of Fn concentration in the estimation of the evolution of connective tissue diseases are discussed.
对40例结缔组织病患者的血浆纤维连接蛋白（Fn）水平进行了研究。发现类风湿关节炎患者的Fn浓度升高（均值±标准误，560±30微克/毫升，p<0.01），混合性结缔组织病患者的Fn浓度降低（337±12微克/毫升，p<0.05），而系统性红斑狼疮、硬皮病、多发性肌炎患者的Fn浓度与对照组无显著差异。发现活动性疾病患者的血浆Fn水平升高，有冷沉淀物的病例中Fn水平降低。讨论了可能影响血浆Fn水平的因素以及利用Fn浓度变化评估结缔组织病病情演变的可能性。
