Shmeleva E A, Kondrashina N N, Beresten' S F, Markina S S, Arzhevitina K V
Zh Mikrobiol Epidemiol Immunobiol. 1988 Dec(12):100-3.
The enzyme immunoassay system for the detection of specific antibacterial antibodies to Corynebacterium diphtheriae membrane protein (mol. wt. 64 KD) has been used. The physicochemical nature of these antibacterial antibodies has been established and their quantitative characteristics have been determined. The analysis of the dynamics of the formation of antimicrobial IgG- and IgM-antibodies in diphtheria patients (on days 3-28 of the disease) has shown that by the time of convalescence the antibody level increases about 200-fold (p less than 0.0001). The possibility of using the dynamics of the formation of specific antimicrobial IgM-antibodies for the serodiagnosis of carrier state is shown, even if the increase of the level of antimicrobial IgG-antibodies is insufficient for this purpose (not more than twofold).
已使用用于检测针对白喉棒状杆菌膜蛋白（分子量64千道尔顿）的特异性抗菌抗体的酶免疫分析系统。已确定这些抗菌抗体的物理化学性质并测定了其定量特征。对白喉患者（疾病第3 - 28天）抗菌IgG和IgM抗体形成动态的分析表明，到康复时抗体水平增加约200倍（p小于0.0001）。研究表明，即使抗菌IgG抗体水平的升高不足以用于此目的（不超过两倍），利用特异性抗菌IgM抗体形成动态进行带菌状态血清学诊断也是可行的。
