在反常屈光状态的角膜中，使用光学相干断层扫描测量角膜和亚层厚度的可重复性。
Repeatability of Cornea and Sublayer Thickness Measurements Using Optical Coherence Tomography in Corneas of Anomalous Refractive Status.
出版信息
J Refract Surg. 2019 Sep 1;35(9):600-605. doi: 10.3928/1081597X-20190806-03.
PURPOSE
To assess the repeatability of epithelial, stromal, and total corneal thickness measurements with spectral-domain optical coherence tomography (SD-OCT; RTVue-XR; Optovue, Inc., Fremont, CA) in patients with myopia, keratoconus, and corneas after transepithelial photorefractive keratectomy (PRK), small incision lenticule extraction (SMILE), and femtosecond laser-assisted in situ keratomileusis (FS-LASIK).
METHODS
A total of 352 eyes of 352 patients (75 myopic, 68 post-transepithelial PRK, 61 post-SMILE, 75 post-FS-LASIK, 20 mild keratoconus, and 53 advanced keratoconus eyes) were included. The epithelial, stromal, and total corneal thickness were recorded from the pachymetric map in the following four zones: (1) central 2-mm region, (2) eight paracentral regions within 2- to 5-mm diameter, (3) eight midperipheral regions within 5- to 7-mm diameter, and (4) eight peripheral regions within 7- to 9-mm diameter. Three successive scans were performed to evaluate the repeatability.
RESULTS
For all zones up to 9-mm diameter, the coefficient of variation (CoV) for epithelial thickness measurements ranged from 1.7% to 3.5% for myopia, 2.6% to 6.2% for post-transepithelial PRK, 2.3% to 4.7% for post-SMILE, 4.0% to 6.3% for post-FS-LASIK, 2.5% to 6.2% for mild keratoconus, and 3.5% to 8.0% for advanced keratoconus. The CoV for stromal and total thickness measurements ranged from 0.2% to 2.0% for myopia, 0.7% to 4.2% for post-transepithelial PRK, 0.3% to 2.4% for post-SMILE, 0.3% to 1.9% for post-FS-LASIK, 0.6% to 3.0% for mild keratoconus, and 1.0% to 5.9% for advanced keratoconus.
CONCLUSIONS
RTVue-XR SD-OCT showed excellent repeatability when generating the pachymetric map in myopic eyes. Measurements, especially for epithelial thickness, were relatively more variable for corneas with keratoconus and those having undergone keratorefractive surgery. [J Refract Surg. 2019;35(9):600-605.].
目的
评估频域光学相干断层扫描（SD-OCT；RTVue-XR；Optovue，Inc.，弗里蒙特，加利福尼亚州）在近视、圆锥角膜和经上皮准分子激光角膜切削术（PRK）、小切口角膜透镜切除术（SMILE）和飞秒激光原位角膜磨镶术（FS-LASIK）后角膜中上皮、基质和总角膜厚度测量的重复性。
方法
共纳入 352 只眼 352 例患者（75 例近视、68 例经上皮 PRK 后、61 例 SMILE 后、75 例 FS-LASIK 后、20 例轻度圆锥角膜和 53 例进展性圆锥角膜）。从角膜地形图的四个区域记录上皮、基质和总角膜厚度：（1）中央 2mm 区域，（2）2-5mm 直径内的 8 个旁中央区域，（3）5-7mm 直径内的 8 个中周边区域，以及（4）7-9mm 直径内的 8 个周边区域。进行三次连续扫描以评估重复性。
结果
对于所有直径达 9mm 的区域，近视患者上皮厚度测量的变异系数（CoV）为 1.7%至 3.5%，经上皮 PRK 后为 2.6%至 6.2%，SMILE 后为 2.3%至 4.7%，FS-LASIK 后为 4.0%至 6.3%，轻度圆锥角膜为 2.5%至 6.2%，进展性圆锥角膜为 3.5%至 8.0%。基质和总厚度测量的 CoV 为近视患者 0.2%至 2.0%，经上皮 PRK 后为 0.7%至 4.2%，SMILE 后为 0.3%至 2.4%，FS-LASIK 后为 0.3%至 1.9%，轻度圆锥角膜为 0.6%至 3.0%，进展性圆锥角膜为 1.0%至 5.9%。
结论
RTVue-XR SD-OCT 在生成近视眼的角膜地形图时显示出极好的重复性。对于圆锥角膜和接受角膜屈光手术的角膜，测量值，特别是上皮厚度，相对更具变异性。[J Refract Surg. 2019;35(9):600-605.]。
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