Xu Zhe, Chen Sisi, Yang Chun, Huang Shenghai, Shen Meixiao, Wang Yuanyuan
School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China.
Ophthalmic Res. 2018;59(3):115-125. doi: 10.1159/000478985. Epub 2017 Aug 19.
To investigate the repeatability and reproducibility of mapping the entire corneal thickness using spectral domain optical coherence tomography (SD-OCT).
Thirty normal eyes, 30 post-laser in situ keratomileusis (LASIK) surgery eyes, and 30 keratoconus eyes were analyzed. A custom-built long scan depth SD-OCT device was used to obtain entire corneal images. Ten-millimeter-diameter corneal thickness maps were generated by an automated segmentation algorithm. Intraclass correlation coefficients of repeatability (ICC1) and reproducibility (ICC2), and coefficients of repeatability (CoR1) and reproducibility (CoR2), were calculated to quantify the precision and accuracy of corneal pachymetry measurements using the Bland-Altman method.
For SD-OCT measurements in healthy subjects, CoR1 and CoR2 were less than 5.00 and 5.53 μm. ICC1 and ICC2 were more than 0.997 and 0.996. For SD-OCT measurements in LASIK patients, CoR1 and CoR2 were less than 5.09 and 5.34 μm. ICC1 and ICC2 were more than 0.997 and 0.996. For SD-OCT measurements in keratoconus patients, CoR1 and CoR2 were less than 11.57 and 10.92 μm. ICC1 and ICC2 were more than 0.995 and 0.996.
The measurements of corneal pachymetric mapping by long scan depth SD-OCT can be assessed over the entire corneal area with good repeatability and reproducibility.
研究使用光谱域光学相干断层扫描（SD-OCT）测量整个角膜厚度的可重复性和再现性。
分析30只正常眼、30只准分子原位角膜磨镶术（LASIK）术后眼和30只圆锥角膜眼。使用定制的长扫描深度SD-OCT设备获取整个角膜图像。通过自动分割算法生成直径为10毫米的角膜厚度图。使用Bland-Altman方法计算重复性组内相关系数（ICC1）和再现性组内相关系数（ICC2），以及重复性系数（CoR1）和再现性系数（CoR2），以量化角膜测厚测量的精度和准确性。
对于健康受试者的SD-OCT测量，CoR1和CoR2分别小于5.00和5.53μm。ICC1和ICC2分别大于0.997和0.996。对于LASIK患者的SD-OCT测量，CoR1和CoR2分别小于5.09和5.34μm。ICC1和ICC2分别大于0.997和0.996。对于圆锥角膜患者的SD-OCT测量，CoR1和CoR2分别小于11.57和10.92μm。ICC1和ICC2分别大于0.995和0.996。
长扫描深度SD-OCT测量角膜厚度图在整个角膜区域具有良好的可重复性和再现性。
