Département de Psychologie, Université de Montréal, Québec, Canada.
Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Québec, Canada.
Hippocampus. 2019 Nov;29(11):1127-1132. doi: 10.1002/hipo.23156. Epub 2019 Sep 9.
The goal of the study was to determine whether the semantic variant of primary progressive aphasia (svPPA) affects the intrinsic connectivity network anchored to left and right anterior hippocampus, but spares the posterior hippocampus. A resting-state functional connectivity MRI (rs-fcMRI) study was conducted in a group of patients with svPPA and in controls, using a seed-to-voxel approach. In comparison to controls, massively reduced connectivity was found in the anterior hippocampus, mainly the left one, for svPPA patients but not in the left or right posterior hippocampus. In svPPA, the anterior hippocampus showed reduced functional connectivity with regions implicated in the semantic memory network. Significant correlation was also found between the functional connectivity strength of the left anterior hippocampus and the ventromedial cortex, and performance in semantic tasks. These findings indicate that the functional disconnection of the anterior hippocampus may be a promising in vivo biomarker of svPPA and illustrate the role of this hippocampal subregion in the semantic memory system.
本研究旨在确定原发性进行性失语症（svPPA）的语义变体是否会影响以左右前海马为锚定点的内在连通性网络，但不会影响后海马。使用种子到体素方法，对一组 svPPA 患者和对照组进行了静息状态功能连接磁共振成像（rs-fcMRI）研究。与对照组相比，svPPA 患者的前海马（主要是左侧）的连接性大大降低，但左侧或右侧后海马没有降低。在 svPPA 中，前海马与语义记忆网络中涉及的区域的功能连接减少。还发现左侧前海马的功能连接强度与腹内侧皮层以及语义任务的表现之间存在显著相关性。这些发现表明，前海马的功能连接中断可能是 svPPA 的有前途的体内生物标志物，并说明了该海马亚区在语义记忆系统中的作用。
