Shenzhen Grubbs Institute and Department of Chemistry , Southern University of Science and Technology , 1088 Xueyuan Boulevard , Shenzhen 518055 , China.
State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road , Shanghai 201203 , China.
Org Lett. 2019 Sep 20;21(18):7493-7497. doi: 10.1021/acs.orglett.9b02787. Epub 2019 Sep 9.
An efficient rhodium-catalyzed enantioselective arylation of isatin-derived -Boc ketimines with arylboroxines has been developed using H-BINOL-derived phosphite-olefin as a chiral ligand. This method allows access to a broad variety of valuable tetrasubstituted 3-amino-2-oxindole derivatives in good yields (up to 98%) with excellent enantioselectivities (up to 98% ee).
一种高效的铑催化的对映选择性芳基化反应，使用 H-BINOL 衍生的亚磷酸酯-烯烃作为手性配体，对来自色胺的 -Boc 酮亚胺与芳基硼酸进行反应。该方法可以得到广泛的有价值的四取代 3-氨基-2-氧吲哚衍生物，产率高（高达 98%），对映选择性好（高达 98%ee）。
