评估具有复发性喉神经病变的马的疑核内的病理变化：一种极端的、长度依赖性的轴索性神经病。
Assessing pathological changes within the nucleus ambiguus of horses with recurrent laryngeal neuropathy: An extreme, length-dependent axonopathy.
机构信息
Comparative Neuromuscular Disease Laboratory, Department of Clinical Sciences and Services, Royal Veterinary College, University of London, London, UK.
出版信息
Muscle Nerve. 2019 Dec;60(6):762-768. doi: 10.1002/mus.26699. Epub 2019 Oct 9.
INTRODUCTION
Equine recurrent laryngeal neuropathy (RLN) is a naturally occurring model of length-dependent axonopathy characterized by asymmetrical degeneration of recurrent laryngeal nerve axons (RLn). Distal RLn degeneration is marked, but it is unclear whether degeneration extends to include cell bodies (consistent with a neuronopathy).
METHODS
With examiners blinded to RLN severity, brainstem location, and side, we examined correlations between RLN severity (assessed using left distal RLn myelinated axon count) and histopathological features (including chromatolysis and glial responses) in the nucleus ambiguus cell bodies, and myelinated axon count of the right distal RLn of 16 horses.
RESULTS
RLN severity was not associated with RLn cell body number (P > .05), or degeneration. A positive correlation between the left and right distal RLn myelinated axon counts was identified (R = 0.57, P < .05).
DISCUSSION
We confirm that RLN, a length-dependent distal axonopathy, occurs in the absence of detectable neuronopathy.
简介
马属复发性喉神经病变（RLN）是一种自然发生的、以长度依赖性轴突病为特征的模型，其特征是复发性喉神经轴突（RLn）的不对称性退行性变。远端 RLn 变性很明显，但尚不清楚是否包括细胞体（与神经元病一致）。
方法
在对 RLN 严重程度、脑干位置和侧别不知情的情况下，我们检查了 16 匹马的 RLN 严重程度（通过左远端 RLn 有髓神经轴突计数评估）与疑核细胞体的组织病理学特征（包括色氨酸溶解和神经胶质反应）以及右侧远端 RLn 有髓神经轴突计数之间的相关性。
结果
RLN 严重程度与 RLn 细胞体数量（P>.05）或变性无关。还发现左、右远端 RLn 有髓神经轴突计数之间存在正相关（R=0.57，P<.05）。
讨论
我们证实，RLN 是一种长度依赖性的远端轴突病，在没有可检测到的神经元病的情况下发生。
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