人牙源性囊肿衬里中糖胺聚糖的定量与分析。

Quantification and analysis of the glycosaminoglycans in human odontogenic cyst linings.

作者信息

Smith G, Smith A J, Browne R M

机构信息

Department of Oral Pathology, University of Birmingham, Dental School, England, U.K.

出版信息

Arch Oral Biol. 1988;33(9):623-6. doi: 10.1016/0003-9969(88)90113-6.

DOI:10.1016/0003-9969(88)90113-6

PMID:3149891

Abstract

Glycosaminoglycans (GAG) were extracted from the connective tissue of 15 dental cysts, 2 dentigerous cysts and 7 keratocysts, and separated electrophoretically and chromatographically. Hyaluronic acid (dental, 2.38; dentigerous, 3.98; keratocyst, 3.19 micrograms uronic acid/mg lyophilized tissue) was the major GAG detected, with lesser amounts of heparin (dental, 1.70; dentigerous, 1.95; keratocyst, 1.80 micrograms uronic acid/mg lyophilized tissue) and chrondroitin-4-sulphate (dental, 1.33; dentigerous, 2.85; keratocyst, 1.37 micrograms uronic acid/mg lyophilized tissue). It is suggested that enzymic release of these GAGs allows their diffusion into the luminal fluid where they may contribute to expansile cyst growth.

摘要

从15个牙囊肿、2个含牙囊肿和7个角化囊肿的结缔组织中提取糖胺聚糖（GAG），并通过电泳和色谱法进行分离。检测到的主要GAG是透明质酸（牙囊肿，2.38；含牙囊肿，3.98；角化囊肿，3.19微克糖醛酸/毫克冻干组织），肝素（牙囊肿，1.70；含牙囊肿，1.95；角化囊肿，1.80微克糖醛酸/毫克冻干组织）和硫酸软骨素-4（牙囊肿，1.33；含牙囊肿，2.85；角化囊肿，1.37微克糖醛酸/毫克冻干组织）的含量较少。有人提出，这些GAG的酶促释放使其扩散到管腔内液中，在那里它们可能有助于囊肿的扩张性生长。