Jaafari-Ashkavandi Zohreh, Tuyeh Ahmad Alipour, Assar Sepideh
Department of Oral & Maxillofacial Pathology, Shiraz Dental School, Shiraz University of Medical Sciences, Shiraz, Iran.
Shiraz Dental School, Shiraz University of Medical Sciences, Shiraz, Iran.
Acta Medica (Hradec Kralove). 2018;61(1):17-21. doi: 10.14712/18059694.2018.18.
CDC7 is a serine/threonine kinase which has an essential role in initiation of DNA proliferation and S phase. It increases the invasion and proliferation in many pathologic lesions. This study aimed to evaluate the expression of CDC7 in the most common odontogenic cysts. We evaluated 17 dentigerous cysts, 18 odontogenic keratocysts (OKC) and 13 radicular cysts immunohistochemically. The mean expression of CDC7 was analyzed using ANOVA and Post-HOC methods. All specimens revealed CDC7 expression. Higher expression of CDC7 in OKC and radicular cyst was shown in comparison to dentigerous cyst (P < 0.001), while radicular cyst and OKC groups showed no difference in CDC7 expression (P = 0.738). The high expression of CDC7 in OKC suggests that this protein could be related to the higher proliferation rate and invasiveness of OKC. On the other hand, the higher CDC7 expression in radicular cyst may simply be related to inflammation as this cyst is neither aggressive nor invasive.
细胞周期蛋白依赖性激酶7（CDC7）是一种丝氨酸/苏氨酸激酶，在DNA增殖起始和S期发挥重要作用。它在许多病理病变中可促进侵袭和增殖。本研究旨在评估CDC7在最常见牙源性囊肿中的表达情况。我们采用免疫组织化学方法评估了17例含牙囊肿、18例牙源性角化囊肿（OKC）和13例根尖囊肿。使用方差分析和事后检验方法分析CDC7的平均表达情况。所有标本均显示有CDC7表达。与含牙囊肿相比，OKC和根尖囊肿中CDC7表达较高（P < 0.001），而根尖囊肿组和OKC组在CDC7表达上无差异（P = 0.738）。OKC中CDC7的高表达表明该蛋白可能与OKC较高的增殖率和侵袭性有关。另一方面，根尖囊肿中较高的CDC7表达可能仅仅与炎症有关，因为该囊肿既不具有侵袭性也不具有转移性。
