Li T J, Browne R M, Matthews J B
Department of Oral Pathology, Kagoshima University Dental School, Japan.
Br J Oral Maxillofac Surg. 1997 Aug;35(4):275-9. doi: 10.1016/s0266-4356(97)90047-4.
To investigate the immunocytochemical expression of parathyroid-hormone-related protein (PTHrP) in odontogenic jaw cysts.
Retrospective study of archival tissue.
University department, UK.
Odontogenic keratocysts (n=27), and dentigerous and radicular cysts (n=10 each).
Immunocytochemistry by biotin streptavidin technique.
Intensity of staining of PTHrP determined by TV image analysis.
The epithelial linings of all the odontogenic keratocysts, 9/10 dentigerous, and 8/10 radicular cysts showed reactivity for PTHrP mainly localised to the basal and suprabasal layers. Odontogenic keratocyst linings expressed significantly higher levels of PTHrP than those of dentigerous and radicular cysts (P<0.003 in each case). There were no differences in epithelial expression of PTHrP between solitary, recurrent and naevoid basal cell carcinoma syndrome-associated odontogenic keratocysts. The fibrous tissue walls of all types of cyst reacted strongly for PTHrP with a trend towards decreasing intensity from odontogenic keratocysts, to dentigerous and then radicular cysts.
It is possible that PTHrP modulates growth and bone resorption in odontogenic cysts. PTHrP may act synergistically with interleukin-1 to increase bone resorption or stimulate osteoblasts and inhibit osteoclasts (resulting in reduced resorption) via its transforming growth factor beta-like activity.
研究甲状旁腺激素相关蛋白（PTHrP）在牙源性颌骨囊肿中的免疫细胞化学表达。
对存档组织的回顾性研究。
英国大学科室。
牙源性角化囊肿（n = 27）、含牙囊肿和根尖囊肿（各n = 10）。
采用生物素-链霉亲和素技术进行免疫细胞化学检测。
通过电视图像分析确定PTHrP的染色强度。
所有牙源性角化囊肿的上皮衬里、9/10的含牙囊肿和8/10的根尖囊肿对PTHrP呈反应性，主要定位于基底层和基底上层。牙源性角化囊肿衬里表达的PTHrP水平显著高于含牙囊肿和根尖囊肿（每种情况P < 0.003）。孤立性、复发性和痣样基底细胞癌综合征相关牙源性角化囊肿之间PTHrP的上皮表达无差异。所有类型囊肿的纤维组织壁对PTHrP反应强烈，从牙源性角化囊肿到含牙囊肿再到根尖囊肿，强度有降低趋势。
PTHrP可能调节牙源性囊肿的生长和骨吸收。PTHrP可能与白细胞介素-1协同作用，通过其转化生长因子β样活性增加骨吸收或刺激成骨细胞并抑制破骨细胞（导致吸收减少）。
