Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Center for Chronic Pruritus, Department of Dermatology, University of Münster, Münster, Germany.
J Am Acad Dermatol. 2020 May;82(5):1117-1123. doi: 10.1016/j.jaad.2019.08.072. Epub 2019 Sep 6.
Because of reduced mortality, patients with HIV are living longer and presenting with chronic diseases. Little is known about racial differences in dermatologic conditions associated with HIV infection.
This study examines associated dermatologic conditions in a large population of patients with HIV at a tertiary care center with a diverse patient population.
Cross-sectional study of patients with HIV seen between July 14, 2013, and July 14, 2018, in a tertiary health care system. The burden of HIV-related dermatologic conditions was collected by using medical records. Patients with HIV were compared with control individuals of the same race, and significance was assessed using the chi-square test. A Bonferroni correction was performed to control for multiple hypothesis testing.
The study population (N = 4679) was 64.7% male and 69% African American, with 88.7% of patients receiving antiretroviral therapy. African American patients with HIV had a greater risk of oral hairy leukoplakia (odds ratio [OR], 64.49), herpes zoster (OR, 9.27), prurigo nodularis (OR, 8.80), and squamous cell carcinoma (OR, 5.72).
Our data describe patients seen by 1 health care system.
African American patients with HIV may be at increased risk for pruritic disorders compared with race-matched control individuals and white patients with HIV.
由于死亡率降低，HIV 患者的寿命延长，并出现慢性疾病。关于与 HIV 感染相关的皮肤科疾病的种族差异，知之甚少。
本研究在一个拥有多样化患者群体的三级保健中心，调查了大量 HIV 患者中与 HIV 相关的皮肤科疾病。
对 2013 年 7 月 14 日至 2018 年 7 月 14 日期间在三级医疗系统就诊的 HIV 患者进行横断面研究。通过病历收集与 HIV 相关的皮肤科疾病负担。将 HIV 患者与同种族的对照个体进行比较，并使用卡方检验评估其显著性。为了控制多重假设检验，进行了 Bonferroni 校正。
研究人群（N=4679）中 64.7%为男性，69%为非裔美国人，88.7%的患者接受抗逆转录病毒治疗。非裔美国人 HIV 患者患口腔毛状白斑（优势比 [OR]，64.49）、带状疱疹（OR，9.27）、结节性痒疹（OR，8.80）和鳞状细胞癌（OR，5.72）的风险更高。
我们的数据描述了由 1 个医疗系统所看到的患者。
与种族匹配的对照个体和白人 HIV 患者相比，非裔美国人 HIV 患者可能更容易患瘙痒性疾病。
