Davis S, Schumacher M J
JAMA. 1979 Nov 9;242(19):2096-7.
Myasthenia gravis and lymphoma rarely coexist, but the occurrence of myasthenia shortly after the treatment of a patient with poorly differentiated nodular lymphoma suggested that an immunological disorder may have contributed to the development of both diseases; the fundamental defects in this association may be impaired immunological surveillance and impaired regulation of immune responses to autoantigens. The finding of T-cell immunodeificiency, including profound T-cell lymphopenia, impaired delayed hypersensitivity responses, and failure to a thymus-dependent antibody response to Salmonella adelaide flagellin, is consistent with this hypothesis.
重症肌无力与淋巴瘤很少同时存在，但在一名低分化结节性淋巴瘤患者治疗后不久发生重症肌无力，提示免疫紊乱可能在这两种疾病的发生中都起了作用；这种关联的根本缺陷可能是免疫监视受损以及对自身抗原的免疫反应调节受损。T细胞免疫缺陷的发现，包括严重的T细胞淋巴细胞减少、迟发型超敏反应受损以及对阿德莱德沙门氏菌鞭毛蛋白的胸腺依赖性抗体反应缺失，与这一假设相符。
