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一例重症肌无力合并慢性肝炎患者的膜相关自身抗体。

A membrane-associated autoantibody in a case of myasthenia gravis with chronic hepatitis.

作者信息

Fairfax A J, Doniach D, Wells C E

出版信息

Clin Exp Immunol. 1976 Sep;25(3):383-8.

PMID:786517
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1541407/
Abstract

A new antibody reacting with a cell membrane-related antigen is described in a patient with myasthenia gravis and chronic liver disease. The antibody gave a striking peripheral immunofluorescence in all cells tested and did not react with smooth muscle fibres, being distinct from anti-actin and anti-myosin antibodies. The antigen was widely distributed in human and animal tissues. The exact relationship of this antibody to the clinical condition is not obvious but its presence is further evidence of widespread disturbances of humoral immunity in myasthenia gravis.

摘要

在一名患有重症肌无力和慢性肝病的患者中，发现了一种与细胞膜相关抗原发生反应的新抗体。该抗体在所有测试细胞中均呈现出显著的周边免疫荧光，且不与平滑肌纤维发生反应，这使其有别于抗肌动蛋白和抗肌球蛋白抗体。该抗原广泛分布于人和动物组织中。这种抗体与临床病症的确切关系尚不明确，但其存在进一步证明了重症肌无力患者体液免疫存在广泛紊乱。

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本文引用的文献

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SYSTEMIC LUPUS ERYTHEMATOSUS FOLLOWING THYMECTOMY FOR MYSTHENIA GRAVIS. REPORT OF TWO CASES.重症肌无力胸腺切除术后发生系统性红斑狼疮。两例报告。
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Changes in serum complement activity in patients with myasthenia gravis.重症肌无力患者血清补体活性的变化
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Myasthenia gravis as an autoimmune disease: clinical aspects.重症肌无力作为一种自身免疫性疾病：临床方面。
Ann N Y Acad Sci. 1966 Jan 26;135(1):506-16. doi: 10.1111/j.1749-6632.1966.tb45499.x.
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Studies in myasthenia gravis: review of a twenty-year experience in over 1200 patients.重症肌无力研究：1200 多名患者的二十年经验回顾
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An autoantibody with U-specificity in a patient with myasthenia gravis.一名重症肌无力患者体内的一种具有U特异性的自身抗体。
Transfusion. 1972 Jul-Aug;12(4):280-3. doi: 10.1111/j.1537-2995.1972.tb00048.x.
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Reaction of human smooth muscle antibody with thyroid cells.人平滑肌抗体与甲状腺细胞的反应。
Clin Exp Immunol. 1974 Nov;18(3):371-7.
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