Deter R L, Rossavik I K, Hill R M, Cortissoz C, Hadlock F P
Department of Obstetrics/Gynecology, Baylor College of Medicine, Houston, Texas 77030.
J Clin Ultrasound. 1987 Jun;15(5):299-305. doi: 10.1002/jcu.1870150502.
As an indicator of fetal limb growth, change in the femur diaphysis length (FDL) between 15 and 38 weeks, menstrual age, has been evaluated in a longitudinal study of 20 normal fetuses, as determined by prenatal biparietal diameter, head circumference, and abdominal circumference growth patterns as well as postnatal pediatric assessment. Individual FDL growth curves were uniformly parabolic and followed very similar trajectories. The projected start points [mean: 9.7 (+/- 1.5 SD) weeks] for these curves were in complete agreement with embryologic data, and the curves themselves were well characterized by the Rossavik model [R2 99.5 (+/- 0.5 SD)%]. No differences between males and females were detected, and good agreement was obtained between the average longitudinal growth curve and the cross-sectional growth curve derived from a previously studied data set. Individual growth curve standards, determined from Rossavik models based on data obtained before 26.1 weeks, menstrual age, were within 7% of actual measurements in 94% of the 97 time points studied after 26 weeks. These results indicate that the Rossavik model and its associated individual growth curve standards can be used to evaluate the growth of the femur and thus provide an improved means for detecting skeletal dysplasias and fetal growth retardation.
作为胎儿肢体生长的一个指标，在一项对20例正常胎儿的纵向研究中，评估了月经龄15至38周期间股骨骨干长度（FDL）的变化。这些胎儿通过产前双顶径、头围和腹围的生长模式以及产后儿科评估确定为正常。个体FDL生长曲线均呈抛物线形，且轨迹非常相似。这些曲线的预计起始点[平均值：9.7（±1.5标准差）周]与胚胎学数据完全一致，并且曲线本身通过罗萨维克模型得到了很好的描述[R2为99.5（±0.5标准差）%]。未检测到男性和女性之间的差异，并且平均纵向生长曲线与从先前研究数据集得出的横断面生长曲线之间取得了良好的一致性。根据月经龄26.1周之前获得的数据通过罗萨维克模型确定的个体生长曲线标准，在26周后研究的97个时间点中的94%内，与实际测量值的偏差在7%以内。这些结果表明，罗萨维克模型及其相关的个体生长曲线标准可用于评估股骨的生长，从而为检测骨骼发育异常和胎儿生长迟缓提供一种改进的方法。
