Tanaka N, Sekimoto K, Naoe S
Arch Pathol Lab Med. 1976 Feb;100(2):81-6.
Until 1972, Kawasaki disease, or acute febrile infantile mucocutaneous lymph node syndrome (MCLS), was considered in Japan to be a nonfatal disease with a favorable prognosis. Based on the findings from two autopsy cases of MCLS, we believe that sudden and unexpected death during convalescence may be due to arterial lesions, especially those involving the coronary artery, that resemble those of periarteritis nodosa. Of 29 autopsy cases of MCLS, gathered from all over Japan, all exhibited arteritis lesions (eg, aneurysm due to coronary arteritis). Such vascular pathological findings may in fact represent the same entity as infantile periarteritis nodosa. Whether infantile periarteritis nodosa can be identified with the adult type is still debatable. The particular manifestations of infantile periarteritis nodosa might be related to severe vasculitis. Autopsy cases of infantile periarteritis nodosa without MCLS manifestations are being collected and studied.
直到1972年，川崎病，即急性发热性婴儿皮肤黏膜淋巴结综合征（MCLS），在日本一直被认为是一种预后良好的非致命性疾病。基于两例MCLS尸检病例的发现，我们认为恢复期突然意外死亡可能是由于动脉病变，尤其是累及冠状动脉的病变，这些病变类似于结节性多动脉炎的病变。在从日本各地收集的29例MCLS尸检病例中，均表现出动脉炎病变（如冠状动脉炎导致的动脉瘤）。这种血管病理学发现实际上可能代表与婴儿结节性多动脉炎相同的疾病实体。婴儿结节性多动脉炎是否可与成人型相鉴别仍存在争议。婴儿结节性多动脉炎的特殊表现可能与严重的血管炎有关。目前正在收集和研究无MCLS表现的婴儿结节性多动脉炎尸检病例。
