Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, CH-1211 Geneva 4, Switzerland; email:
MRC Centre for Molecular Microbiology and Infection, Department of Life Sciences, Imperial College London, SW7 2AZ London, United Kingdom; email:
Annu Rev Microbiol. 2019 Sep 8;73:387-406. doi: 10.1146/annurev-micro-020518-115555.
The intracellular signaling molecule cyclic di-GMP (c-di-GMP) regulates the lifestyle of bacteria and controls many key functions and mechanisms. In the case of bacterial pathogens, a wide variety of virulence lifestyle factors have been shown to be regulated by c-di-GMP. Evidence of the importance of this molecule for bacterial pathogenesis has become so great that new antimicrobial agents are tested for their capacity of targeting c-di-GMP signaling. This review summarizes the current knowledge on this topic and reveals its application for the development of new antivirulence intervention strategies.
细胞内信号分子环二鸟苷酸（c-di-GMP）调节细菌的生活方式，并控制许多关键功能和机制。在细菌病原体的情况下，已经表明 c-di-GMP 调节多种毒力生活方式因素。该分子对细菌发病机制的重要性的证据已经变得如此之大，以至于新的抗菌剂正在测试其靶向 c-di-GMP 信号的能力。本综述总结了这一主题的最新知识，并揭示了其在开发新的抗毒力干预策略方面的应用。
