Tamayo Rita, Pratt Jason T, Camilli Andrew
Howard Hughes Medical Institute, Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.
Annu Rev Microbiol. 2007;61:131-48. doi: 10.1146/annurev.micro.61.080706.093426.
Cyclic diguanylate (c-di-GMP) is a bacterial second messenger of growing recognition involved in the regulation of a number of complex physiological processes. This review describes the biosynthesis and hydrolysis of c-di-GMP and several mechanisms of regulation of c-di-GMP metabolism. The contribution of c-di-GMP to regulating biofilm formation and motility, processes that affect pathogenesis of many bacteria, is described, as is c-di-GMP regulation of virulence gene expression. Finally, ways in which c-di-GMP may mediate these regulatory effects are proposed.
环二鸟苷酸（c-di-GMP）是一种越来越受到关注的细菌第二信使，参与多种复杂生理过程的调控。本文综述了c-di-GMP的生物合成与水解以及c-di-GMP代谢的几种调控机制。描述了c-di-GMP在调节生物膜形成和运动性方面的作用，这两个过程影响许多细菌的致病性，还介绍了c-di-GMP对毒力基因表达的调控。最后，提出了c-di-GMP介导这些调控作用的方式。
