CRISPR系统与癌症免疫治疗生物标志物。
The CRISPR System and Cancer Immunotherapy Biomarkers.
作者信息
Balan Vitaly, Wang Jianbin
机构信息
Refuge Biotechnologies Inc., Menlo Park, CA, USA.
出版信息
Methods Mol Biol. 2020;2055:301-322. doi: 10.1007/978-1-4939-9773-2_14.
Recent advances in cancer immunotherapy have shed new light on the possibility to cure most, if not all, cancer patients with further development of various treatment options. The emergency of a new genome editing tool, the clustered regularly interspaced short palindromic repeats (CRISPR) technology, revolutionized the biomedical research field. We envision application of the CRISPR technology in cancer research, diagnosis, and therapy will markedly speed up the development of new treatment options for cancer patients. The CRISPR system and its applications in biomedical research will be discussed with an emphasis on cancer immunotherapy and biomarker development.
癌症免疫疗法的最新进展为通过进一步开发各种治疗方案治愈大多数（即便不是全部）癌症患者的可能性带来了新的曙光。一种新的基因组编辑工具——成簇规律间隔短回文重复序列（CRISPR）技术的出现，彻底改变了生物医学研究领域。我们设想，CRISPR技术在癌症研究、诊断和治疗中的应用将显著加速针对癌症患者的新治疗方案的开发。本文将讨论CRISPR系统及其在生物医学研究中的应用，重点是癌症免疫疗法和生物标志物的开发。
Zotero 插件