Ramos-Soto Daniela I, Singh Abhishek K, Saucedo-Casas Edgar, Castro-Camus Enrique, Alfaro-Gomez Mariana
Appl Opt. 2019 Aug 20;58(24):6581-6585. doi: 10.1364/AO.58.006581.
We use terahertz time-domain spectroscopic (THz-TDS) imaging for the evaluation of moisturizing-substances effects over stratum corneum (SC) samples. Excised SC of porcine skin is used as an in vitro skin model. We evaluate the interaction of SC samples with glycerine and lanolin, two substances commonly used in moisturizers. In order to do this, THz images of SC samples after deposition of the substances are scanned. The response of the SC samples to a commercial moisturizer is also analyzed. Our results show that THz imaging is capable of sensing the distinct interaction mechanisms of the substances with the SC samples. The occlusive nature of lanolin, the hyperosmotic behavior of glycerine, and the moisturizing effect of the commercial moisturizer can be observed using THz-TDS imaging.
我们使用太赫兹时域光谱（THz-TDS）成像技术来评估保湿物质对角质层（SC）样本的影响。猪皮肤的离体角质层被用作体外皮肤模型。我们评估了角质层样本与甘油和羊毛脂这两种保湿霜中常用物质的相互作用。为此，我们扫描了涂抹这些物质后角质层样本的太赫兹图像。我们还分析了角质层样本对一款商业保湿霜的反应。我们的结果表明，太赫兹成像能够感知这些物质与角质层样本不同的相互作用机制。使用太赫兹时域光谱成像可以观察到羊毛脂的封闭性、甘油的高渗行为以及商业保湿霜的保湿效果。
