Laboratory for Cardiovascular Regenerative Medicine, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Hanzeplein 1 (EA11), Groningen, The Netherlands.
Department of Cardiology and Pneumology, University Medical Center of Göttingen, Georg-August University, Göttingen, Germany.
Cardiovasc Res. 2019 Oct 1;115(12):1716-1731. doi: 10.1093/cvr/cvz211.
Endothelial-to-mesenchymal transition (EndMT) is the process wherein endothelial cells lose their typical endothelial cell markers and functions and adopt a mesenchymal-like phenotype. EndMT is required for development of the cardiac valves, the pulmonary and dorsal aorta, and arterial maturation, but activation of the EndMT programme during adulthood is believed to contribute to several pathologies including organ fibrosis, cardiovascular disease, and cancer. Non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, modulate EndMT during development and disease. Here, we review the mechanisms by which non-coding RNAs facilitate or inhibit EndMT during development and disease and provide a perspective on the therapeutic application of non-coding RNAs to treat fibroproliferative cardiovascular disease.
内皮-间充质转化（EndMT）是指内皮细胞失去其典型的内皮细胞标志物和功能，并采用间充质样表型的过程。EndMT 是心脏瓣膜、肺和背主动脉以及动脉成熟发育所必需的，但成年期 EndMT 程序的激活被认为会导致多种病理，包括器官纤维化、心血管疾病和癌症。非编码 RNA，包括 microRNAs、长非编码 RNA 和环状 RNA，在发育和疾病过程中调节 EndMT。在这里，我们综述了非编码 RNA 在发育和疾病过程中促进或抑制 EndMT 的机制，并就非编码 RNA 治疗纤维增生性心血管疾病的治疗应用提供了一个视角。
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