Wang Haitao, Sun Kai, Peng Hao, Wang Yi, Zhang Lei
Department of Pulmonary and Critical Care Medicine, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, China.
Xianning Medical College, Hubei University of Science & Technology, Xianning, 437000, Hubei, China.
Cell Death Discov. 2024 Oct 21;10(1):443. doi: 10.1038/s41420-024-02170-5.
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic lung disease with limited treatment options and efficacy. Evidence suggests that IPF arises from genetic, environmental, and aging-related factors. The pathogenic mechanisms of IPF primarily involve dysregulated repeated microinjuries to epithelial cells, abnormal fibroblast/myofibroblast activation, and extracellular matrix (ECM) deposition, but thus far, the exact etiology remains unclear. Noncoding RNAs (ncRNAs) play regulatory roles in various biological processes and have been implicated in the pathophysiology of multiple fibrotic diseases, including IPF. This review summarizes the roles of ncRNAs in the pathogenesis of IPF and their potential as diagnostic and therapeutic targets.
特发性肺纤维化（IPF）是一种慢性、进行性纤维化肺部疾病，治疗选择和疗效有限。有证据表明，IPF源于遗传、环境和衰老相关因素。IPF的致病机制主要涉及上皮细胞反复微损伤失调、成纤维细胞/肌成纤维细胞异常激活以及细胞外基质（ECM）沉积，但迄今为止，确切病因仍不清楚。非编码RNA（ncRNAs）在各种生物过程中发挥调节作用，并已被证明与包括IPF在内的多种纤维化疾病的病理生理学有关。本综述总结了ncRNAs在IPF发病机制中的作用及其作为诊断和治疗靶点的潜力。
