Henan Key Laboratory of Medical Tissue Regeneration, 91593Xinxiang Medical University, Xinxiang, Henan, China.
J Cardiovasc Pharmacol Ther. 2021 Jan;26(1):3-11. doi: 10.1177/1074248420952233. Epub 2020 Aug 27.
Endothelial-to-mesenchymal transition (EndMT) is a complex biological process by which endothelial cells lose their endothelial cell characteristics and acquire mesenchymal cell properties under certain physiological or pathological conditions. Recently, it has been found that EndMT plays an important role in the occurrence and development of fibrotic cardiovascular diseases. In this review, we first summarize the main induction pathways involved in EndMT process. In addition, we discuss the role of EndMT in fibrotic cardiovascular diseases and its potential implication in new therapeutic interventions.
内皮-间充质转化（EndMT）是一种复杂的生物学过程，即在某些生理或病理条件下，内皮细胞失去内皮细胞特征并获得间充质细胞特性。最近发现，EndMT 在纤维性心血管疾病的发生和发展中起着重要作用。在这篇综述中，我们首先总结了参与 EndMT 过程的主要诱导途径。此外，我们还讨论了 EndMT 在纤维性心血管疾病中的作用及其在新的治疗干预中的潜在意义。
