Tanaka A, O'Sullivan F X, Koopman W J, Gay S
Institute of Dental Research, University of Alabama, Birmingham 35294.
J Oral Pathol. 1988 Nov;17(9-10):460-5. doi: 10.1111/j.1600-0714.1988.tb01316.x.
Salivary glands of autoimmune MRL/l mice were examined ultrastructurally and by immunoelectron microscopy to further characterize the Sjögren's syndrome-like disease in these animals. Major salivary glands from 12 female and 7 male MRL/l, two female MRL/n, and one female BALB/c mice were examined by electron microscopy and the glands from 4 female MRL/l mice were subjected to immunoelectron microscopy in order to detect Lyt-1 and Lyt-2 positive lymphoid cells. Mononuclear cell infiltrates were not seen in the salivary gland from the BALB mouse and occurred rarely in glands of MRL/n mice. However, in MRL/l mice, numerous lymphoid cells were present and acinar cells displayed low cytoplasmic density, cytoplasmic vacuolization and cellular lysis. Lymphoid cells were predominantly Lyt-1 positive although some Lyt-2 positive cells were observed. These results suggest that the MRL/l mouse represents a useful model for the study of the pathogenesis of Sjögren's syndrome in man.
对自身免疫性MRL/l小鼠的唾液腺进行了超微结构检查和免疫电子显微镜检查，以进一步明确这些动物中类似干燥综合征的疾病特征。通过电子显微镜检查了12只雌性和7只雄性MRL/l小鼠、2只雌性MRL/n小鼠以及1只雌性BALB/c小鼠的主要唾液腺，并对4只雌性MRL/l小鼠的唾液腺进行了免疫电子显微镜检查，以检测Lyt-1和Lyt-2阳性淋巴细胞。在BALB小鼠的唾液腺中未观察到单核细胞浸润，在MRL/n小鼠的唾液腺中也很少出现。然而，在MRL/l小鼠中，存在大量淋巴细胞，腺泡细胞显示出低细胞质密度、细胞质空泡化和细胞溶解。淋巴细胞主要为Lyt-1阳性，尽管也观察到一些Lyt-2阳性细胞。这些结果表明，MRL/l小鼠是研究人类干燥综合征发病机制的有用模型。
