Raubenheimer E J, Dauth J, Pretorius F J
Department of Oral Pathology, Medical University of Southern Africa.
J Oral Pathol. 1988 Nov;17(9-10):554-9. doi: 10.1111/j.1600-0714.1988.tb01333.x.
Tongue biopsies of 30 diagnosed cases of multiple myeloma were examined light and electron microscopically and amyloid deposits were identified in 8 patients. Immunochemical typing of amyloid in kappa and lambda subtypes was performed successfully although positive staining of tissue-associated immunoglobulin light chains made reliable identification of amyloid with this technique difficult. Cells of macrophage lineage appear to play a central role in light chain-associated amyloidogenesis. Our findings do not agree with the reported higher amyloidogenic potential of lambda light chains and we were unable to show a positive correlation between the percentage plasma cells in bone marrow aspirates or the presence of urinary light chains and myeloma-associated amyloidosis.
对30例确诊的多发性骨髓瘤患者的舌活检组织进行了光镜和电镜检查，发现8例患者存在淀粉样沉积物。尽管组织相关免疫球蛋白轻链的阳性染色使得用该技术可靠鉴定淀粉样蛋白变得困难，但仍成功进行了κ和λ亚型淀粉样蛋白的免疫化学分型。巨噬细胞系细胞似乎在轻链相关淀粉样变的发生中起核心作用。我们的研究结果与报道的λ轻链具有更高淀粉样变潜能不一致，并且我们未能显示骨髓穿刺液中浆细胞百分比或尿轻链的存在与骨髓瘤相关淀粉样变性之间存在正相关。
