Department of Integrative Biology, University of Texas, Austin, TX 78712, USA.
Department of Biological Sciences, Auburn University, Auburn, AL 36849, USA.
Integr Comp Biol. 2019 Oct 1;59(4):856-863. doi: 10.1093/icb/icz132.
Eukaryotes are the outcome of an ancient symbiosis and as such, eukaryotic cells fundamentally possess two genomes. As a consequence, gene products encoded by both nuclear and mitochondrial genomes must interact in an intimate and precise fashion to enable aerobic respiration in eukaryotes. This genomic architecture of eukaryotes is proposed to necessitate perpetual coevolution between the nuclear and mitochondrial genomes to maintain coadaptation, but the presence of two genomes also creates the opportunity for intracellular conflict. In the collection of papers that constitute this symposium volume, scientists working in diverse organismal systems spanning vast biological scales address emerging topics in integrative, comparative biology in light of mitonuclear interactions.
真核生物是古老共生的结果，因此，真核细胞从根本上拥有两个基因组。因此，核基因组和线粒体基因组编码的基因产物必须以一种亲密而精确的方式相互作用，以使真核生物能够进行有氧呼吸。真核生物的这种基因组结构被认为需要核基因组和线粒体基因组之间不断的共同进化，以维持共适应，但两个基因组的存在也为细胞内冲突创造了机会。在构成本期专题的论文集中，来自不同生物系统的科学家跨越了广阔的生物学尺度，根据线粒体与核相互作用，探讨了综合比较生物学中新兴的课题。
