School of Medicine and Public Health, University of Newcastle, Callaghan, Australia.
Hunter Medical Research Institute, New Lambton, Australia.
Diabet Med. 2019 Nov;36(11):1487-1493. doi: 10.1111/dme.14133. Epub 2019 Sep 20.
Overweight and obesity are frequently reported in young persons with type 1 diabetes, however its relative magnitude in comparison to the general population is not well understood. This study compared the prevalence of overweight and obesity in young persons with type 1 diabetes to a reference population and explored possible associated factors, including gender, age, HbA , insulin regimen, age at diagnosis, diabetes duration, socio-economic status and cardiovascular disease risk factors.
A cross-sectional review was undertaken of data collected from youth (3-17 years) in 2016 and young adults (18-30 years) in 2015 with a diagnosis of type 1 diabetes for > 3 months attending diabetes centres in Newcastle, Australia. Rates of overweight and obesity were compared with matched population survey results.
Data from 308 youth and 283 young adults were included. In girls, significantly higher prevalence of overweight and obesity were seen in the 5-8 (43% vs. 18%), 13-16 (41% vs. 27%), 18-24 (46% vs. 34%) and 25-30 (60% vs. 43%) years age groups; whereas in boys increased prevalence was observed in the 5-8 years age group only (41% vs. 18%). Rates of overweight and obesity increased with age across sexes. In youth, BMI standard deviation score was correlated with socio-economic status, insulin regimen, blood pressure and blood lipids (P < 0.05). In adults, BMI was positively associated with blood pressure, and longer diabetes duration (P < 0.02).
Overweight and obesity are over-represented in young persons with type 1 diabetes, particularly girls. As overweight is associated with other cardiovascular disease markers early intervention is paramount.
1 型糖尿病患者中常报告超重和肥胖,但与普通人群相比,其相对程度尚不清楚。本研究比较了 1 型糖尿病青少年与参考人群的超重和肥胖患病率,并探讨了可能的相关因素,包括性别、年龄、HbA1c、胰岛素方案、诊断年龄、糖尿病病程、社会经济地位和心血管疾病危险因素。
对 2016 年和 2015 年在澳大利亚纽卡斯尔的糖尿病中心就诊的年龄在 3-17 岁的青少年(诊断 1 型糖尿病>3 个月)和年龄在 18-30 岁的年轻人进行了横断面回顾性分析。将超重和肥胖的发生率与匹配的人群调查结果进行比较。
共纳入 308 名青少年和 283 名年轻人的数据。在女孩中,5-8 岁(43%比 18%)、13-16 岁(41%比 27%)、18-24 岁(46%比 34%)和 25-30 岁(60%比 43%)年龄组的超重和肥胖患病率显著更高;而在男孩中,仅在 5-8 岁年龄组观察到患病率增加(41%比 18%)。在两性中,超重和肥胖的发生率随着年龄的增长而增加。在青少年中,BMI 标准差评分与社会经济地位、胰岛素方案、血压和血脂相关(P<0.05)。在成年人中,BMI 与血压和较长的糖尿病病程呈正相关(P<0.02)。
1 型糖尿病青少年中存在超重和肥胖,特别是女孩。超重与其他心血管疾病标志物相关,因此早期干预至关重要。