Department of Clinical Physiology in Kalmar, Region Kalmar County, Kalmar, Sweden.
Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
Sci Rep. 2024 Feb 17;14(1):3982. doi: 10.1038/s41598-024-54597-6.
In adulthood, individuals with type 1 diabetes mellitus may develop a condition of heart failure with preserved ejection fraction. However, subclinical changes to the heart in diabetes are likely to occur prior to the clinical presentation. This cross-sectional study aimed to compare left atrial function by echocardiography between 43 individuals with type 1 diabetes and 43 healthy controls, aged 10-30 years. All participants underwent echocardiography and 2D speckle tracking measurements for left atrial phase function parameters. Physical capacity was assessed by exercise test on a bicycle. Results showed that participants with type 1 diabetes had significantly lower left atrial function parameters than healthy controls (p < 0.05). There was a significant negative correlation between HbA1c means and reservoir and conduit strain (p < 0.05) and individuals with BMI < 30 showed a lower left atrial stiffness (p < 0.05). Individuals with type 1 diabetes and a higher physical capacity did not differ from their healthy peers. Results indicate that lower HbA1c levels, BMI < 30 and a higher physical capacity are favourable in terms of left atrial function in children and young adults with type 1 diabetes mellitus. Left atrial strain by echocardiography might become a new important tool in assessing heart function in T1DM.
在成年期，1 型糖尿病患者可能会发展为射血分数保留的心力衰竭。然而，糖尿病患者的心脏亚临床变化可能在临床症状出现之前就已经发生。本横断面研究旨在比较 43 名 1 型糖尿病患者和 43 名年龄在 10-30 岁的健康对照者的超声心动图左心房功能。所有参与者均接受超声心动图和二维斑点追踪测量左心房相位功能参数检查。身体能力通过自行车运动试验进行评估。结果表明，1 型糖尿病患者的左心房功能参数明显低于健康对照组（p<0.05）。HbA1c 均值与储备和传导应变呈显著负相关（p<0.05），BMI<30 的个体左心房僵硬度较低（p<0.05）。体力活动能力较高的 1 型糖尿病患者与健康同龄人没有差异。结果表明，HbA1c 水平较低、BMI<30 和体力活动能力较高有利于 1 型糖尿病儿童和青少年的左心房功能。超声心动图左心房应变可能成为评估 T1DM 患者心功能的一种新的重要工具。
