长非编码 RNA 与子宫内膜癌。
Long non-coding RNAs and endometrial cancer.
机构信息
Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan, China.
Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan, China.
出版信息
Biomed Pharmacother. 2019 Nov;119:109396. doi: 10.1016/j.biopha.2019.109396. Epub 2019 Sep 7.
Endometrial cancer (EC) is one of the most common gynecologic malignancies. In spite of the advance in chemotherapy, radiotherapy or surgical techniques for EC in recent years, the survival rate of advanced stage EC patients remains unsatisfactory. Long non-coding RNAs (lncRNAs) are known as transcripts longer than 200 nucleotides exhibiting no or limited protein-coding potential. Growing evidence suggested lncRNAs may be a critical class of pervasive genes involved in cancer progression. However, the function and biological relevance between lncRNAs and EC remain not yet fully understood. Accumulating evidence has indicated that lncRNAs are dysregulated in EC, and closely related to tumorigenesis, metastasis and chemoresistance. In this review, we summarize the known regulation and functional roles of lncRNAs in EC. Besides, we will discuss the potential of lncRNAs as diagnostic biomarkers and therapeutic targets in EC.
子宫内膜癌（EC）是最常见的妇科恶性肿瘤之一。尽管近年来 EC 的化疗、放疗或手术技术有所进步，但晚期 EC 患者的生存率仍不尽人意。长链非编码 RNA（lncRNA）是指长度大于 200 个核苷酸的转录本，不具有或具有有限的蛋白质编码潜力。越来越多的证据表明，lncRNA 可能是一类广泛存在的与癌症进展有关的关键基因。然而，lncRNA 与 EC 之间的功能和生物学相关性仍未完全阐明。越来越多的证据表明，lncRNA 在 EC 中失调，并与肿瘤发生、转移和化疗耐药密切相关。在这篇综述中，我们总结了 lncRNA 在 EC 中的已知调控和功能作用。此外，我们将讨论 lncRNA 作为 EC 诊断生物标志物和治疗靶点的潜力。
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