Liu Lifen, Chen Xin, Zhang Ying, Hu Yanrong, Shen Xiaoqing, Zhu Weipei
Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu, China.
Oncotarget. 2017 May 9;8(19):31386-31394. doi: 10.18632/oncotarget.15607.
It is generally known that the human genome makes a large amount of noncoding RNAs compared with coding genes. Long non-coding RNAs (lncRNAs) which composed of more than 200 nucleotides have been described as the largest subclass of the non-coding transcriptome in human noncoding RNAs. Existing research shows that lncRNAs exerted biological functions in various tumors via participating in both oncogenic and tumor suppressing pathways. The previous studies indicated that lncRNA taurine upregulated 1 (TUG1) play important roles in the initiation and progression of malignancies. In this study,based on previous research, we investigated the expression and biological role of the lncRNA-TUG1. We analyzed the relationship between lncRNA-TUG1and endometrial carcinoma (EC) in a total 104 EC carcinoma specimens, compared with that in normal tissues. We found that lncRNA-TUG1 expression in cancer tissues was significantly higher than that in adjacent tissues. Through a series of experiments, the results demonstrated that lncRNA-TUG1 enhances the evolution and progression of EC through inhibiting miR-299 and miR-34a-5p.
众所周知，与编码基因相比，人类基因组会产生大量的非编码RNA。由200多个核苷酸组成的长链非编码RNA（lncRNA）被认为是人类非编码RNA转录组中最大的亚类。现有研究表明，lncRNA通过参与致癌和抑癌途径在各种肿瘤中发挥生物学功能。先前的研究表明，lncRNA牛磺酸上调1（TUG1）在恶性肿瘤的发生和发展中起重要作用。在本研究中，基于先前的研究，我们调查了lncRNA-TUG1的表达及其生物学作用。我们分析了104例子宫内膜癌（EC）标本中lncRNA-TUG1与子宫内膜癌的关系，并与正常组织进行了比较。我们发现癌组织中lncRNA-TUG1的表达明显高于相邻组织。通过一系列实验，结果表明lncRNA-TUG1通过抑制miR-299和miR-34a-5p促进子宫内膜癌的发展和进展。
