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B族链球菌性脑膜炎的复发

Recurrence of group B streptococcal meningitis.

作者信息

Butler V, Pejoan H, Blot N

机构信息

Service de pédiatrie, centre hospitalier Rives-de-Seine, 36, boulevard du Général-Leclerc, 92205 Neuilly-sur-Seine, France.

Service de pédiatrie, centre hospitalier Rives-de-Seine, 36, boulevard du Général-Leclerc, 92205 Neuilly-sur-Seine, France.

出版信息

Arch Pediatr. 2019 Sep;26(6):374-376. doi: 10.1016/j.arcped.2019.08.003. Epub 2019 Sep 8.

Abstract

Group B Streptococcus is the most frequent cause of neonatal sepsis. However, recurrences are rare. We report a case of recurrent meningitis due to Streptococcus B in a 2-month-old infant. Streptococcus B identified was hypervirulent clone ST-17 serotype III, which is known for its neurotropism. We found five other cases of recurrent group B streptococcal meningitis in the literature, which we report here. Many reports have identified breastfeeding and persistent colonization as the mode of transmission in recurrent Streptococcus B infections. We also discuss different ways to prevent recurrent group B streptococcal infections. Oral antibiotic therapy against carriage does not seem to be effective and there is no consensus on management of breastfeeding.

摘要

B族链球菌是新生儿败血症最常见的病因。然而,复发情况很少见。我们报告一例2个月大婴儿因B族链球菌导致复发性脑膜炎的病例。鉴定出的B族链球菌是高毒力克隆ST-17血清型III,以其嗜神经性而闻名。我们在文献中发现了另外5例复发性B族链球菌脑膜炎病例,并在此报告。许多报告已确定母乳喂养和持续定植是复发性B族链球菌感染的传播方式。我们还讨论了预防复发性B族链球菌感染的不同方法。针对携带状态的口服抗生素治疗似乎无效,并且在母乳喂养的管理方面尚无共识。

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