Goncharova R I, Levina A B, Kuzhir T D
Genetika. 1988 Dec;24(12):2141-8.
The genetic effect of some factors is generally evaluated as an average response of all individuals, without taking into account their potential differences. The presence of individual sensitivity in separate Drosophila organisms to the mutagenic influence of ethyl methanesulfonate was shown when analysing recessive sex-linked lethal mutations in germ cells of males. Different sensitivity of separate individuals to mutagens reflects the existence of cryptic genetic variability in Drosophila strains on a large scale. It is advisable to take into account individual sensitivity of organisms to mutagenic factors, when conducting mutation research and studying genetic consequences of biosphere pollution.
某些因素的遗传效应通常被评估为所有个体的平均反应，而没有考虑到它们潜在的差异。在分析雄性生殖细胞中隐性性连锁致死突变时，发现不同的果蝇个体对甲磺酸乙酯的诱变影响存在个体敏感性。不同个体对诱变剂的不同敏感性反映了果蝇品系中大规模隐性遗传变异的存在。在进行突变研究和研究生物圈污染的遗传后果时，考虑生物体对诱变因素的个体敏感性是明智的。
