• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

[Use of the method of fast atom bombardment mass spectrometry for identification of products of the interaction of thiophosphamide with DNA].

作者信息

Sukhodub L F, Andrievskiĭ G V, Piatigorskaia T L, Kosevich M V, Zhilkova O Iu

出版信息

Bioorg Khim. 1988 Dec;14(12):1698-9.

PMID:3150804
Abstract

Products of interaction between DNA and an antitumour drug N, N', N''-triethylenethiophosphoramide (thiotepa) have been observed for the first time by the fast atom bombardment mass spectrometry. The sites of alkylation are detected as N7 (Gua) and N3 (Ade), and yields of the products are evaluated.

摘要

相似文献

1
[Use of the method of fast atom bombardment mass spectrometry for identification of products of the interaction of thiophosphamide with DNA].
Bioorg Khim. 1988 Dec;14(12):1698-9.
2
Direct observation of the alkylation products of deoxyguanosine and DNA by fast atom bombardment mass spectrometry.通过快原子轰击质谱法直接观察脱氧鸟苷和DNA的烷基化产物
Biol Mass Spectrom. 1991 Nov;20(11):665-8. doi: 10.1002/bms.1200201103.
3
[DNA interaction with the antitumor agent thiophosphamide].
Mol Biol (Mosk). 1986 Mar-Apr;20(2):423-9.
4
The structure of DNA dictates purine atom site selectivity in alkylation by primary diazonium ions.DNA的结构决定了一级重氮离子烷基化时嘌呤原子位点的选择性。
Chem Res Toxicol. 2005 Sep;18(9):1462-70. doi: 10.1021/tx0501334.
5
A search for new metabolites of N,N',N''-triethylenethiophosphoramide.N,N',N''-三乙烯硫代磷酰胺新代谢产物的研究。
Cancer Res. 1999 Sep 15;59(18):4720-4.
6
[Alkylation of nucleic acid components by ethyleneimine derivatives. I. Alkylation of bases].[乙撑亚胺衍生物对核酸成分的烷基化作用。I. 碱基的烷基化]
Bioorg Khim. 1990 Jul;16(7):981-90.
7
Determinants of selectivity in alkylation of nucleosides and DNA by secondary diazonium ions: evidence for, and consequences of, a preassociation mechanism.仲重氮离子对核苷和DNA进行烷基化反应时选择性的决定因素：预缔合机制的证据及其影响
Chem Res Toxicol. 2004 Nov;17(11):1531-9. doi: 10.1021/tx0498004.
8
Alkylation of DNA with aziridine produced during the hydrolysis of N,N',N''-triethylenethiophosphoramide.N,N',N''-三乙烯硫代磷酰胺水解过程中产生的氮丙啶对DNA进行烷基化作用。
Chem Res Toxicol. 1992 Jan-Feb;5(1):95-9. doi: 10.1021/tx00025a016.
9
[The structure of products of modification of nucleotides and DNA by ethyleneimine and thio-TEPA].
Bioorg Khim. 1987 Jun;13(6):786-92.
10
Quantitative and qualitative analysis of DNA methylation at N3-adenine by N-methyl-N-nitrosourea.N-甲基-N-亚硝基脲对N3-腺嘌呤处DNA甲基化的定量和定性分析
Chem Res Toxicol. 1998 Dec;11(12):1481-6. doi: 10.1021/tx9801763.