Khoss A E, Balzar E, Steger H, Howanietz H, Wladika W, Hamilton G, Woloszczuk W
Department of Pediatrics, University Children's Hospital, Vienna, Austria.
Child Nephrol Urol. 1988;9(1-2):46-9.
In the follow-up of children receiving renal allografts the early differential diagnosis of infections and rejection episodes is the main problem. Serum levels of neopterin (N), a pteridine released from stimulated macrophages, was determined by radioimmunoassay. Also interferon-gamma (IF) serum levels, a marker of T lymphocyte activity, were determined with an immunoradiometric assay in 19 kidney-transplanted children. Both, infections and rejection episodes, are accompanied by distinct increases in N. The IF are elevated 1-3 days earlier than N, the median values during infections being significantly (p less than or equal to 0.001) higher than those during rejection crises. The routine measurement of N and IF allow the simple, quick and reliable monitoring of the immune status, which seems to be of a high relevance for the daily monitoring of transplant recipients.
在接受肾移植儿童的随访中，感染与排斥反应发作的早期鉴别诊断是主要问题。采用放射免疫分析法测定了血清新蝶呤（N）水平，新蝶呤是一种由受刺激巨噬细胞释放的蝶啶。还采用免疫放射分析法测定了19名肾移植儿童的血清干扰素-γ（IF）水平，IF是T淋巴细胞活性的标志物。感染和排斥反应发作均伴有N的明显升高。IF比N提前1 - 3天升高，感染期间的中位数显著高于排斥反应危机期间（p≤0.001）。N和IF的常规检测可对免疫状态进行简单、快速且可靠的监测，这似乎对移植受者的日常监测具有高度相关性。
