Aulitzky W E, Tilg H, Niederwieser D, Riccabona G, Obendorf L, Margreiter R, Pfaller W, Huber C
Department of Internal Medicine, University Hospital Innsbruck, Austria.
Clin Nephrol. 1988 May;29(5):248-52.
Determination of serum and urinary neopterin levels was performed daily in 30 patients undergoing kidney transplantation for treatment of end-stage renal failure. Neopterin serum levels were determined by RIA and urinary excretion by HPLC. In parallel, the same samples were tested for creatinine content. Results indicated a strong correlation between the clearance of neopterin and creatinine. This correlation was independent of the extent of functional impairment as well as of the different causes of renal insufficiency. As a consequence, a strong relationship between serum and urinary neopterin levels was only obtained when values were corrected for different renal function by dividing them by the creatinine levels. It thus appears that major attention has to be paid to the functional state of the kidney when studying neopterin serum and/or urine values. It also appears that under these prerequisites both methods of detection as well as both sample sources yield comparable results.
对30例因终末期肾衰竭接受肾移植治疗的患者，每日测定其血清和尿新蝶呤水平。采用放射免疫分析法测定血清新蝶呤水平，高效液相色谱法测定尿排泄量。同时，对相同样本检测肌酐含量。结果表明，新蝶呤清除率与肌酐清除率之间存在强相关性。这种相关性与功能损害程度以及肾功能不全的不同病因无关。因此，只有通过将血清和尿新蝶呤水平除以肌酐水平来校正不同的肾功能时，才能得到血清和尿新蝶呤水平之间的强相关性。由此可见，在研究血清和/或尿新蝶呤值时，必须高度重视肾脏的功能状态。在这些前提下，两种检测方法以及两种样本来源似乎都能产生可比的结果。
