同时给予碘番酸和促甲状腺激素释放激素（TRH）对甲状腺功能正常受试者甲状腺激素代谢的影响。

Effect of simultaneously administered iopanoic acid and thyrotropin releasing hormone (TRH) on thyroid hormone metabolism in euthyroid subjects.

作者信息

Szabolcs I, Kovács Z, Góth M, Szilágyi G

机构信息

Postgraduate Medical School, I. Department of Internal Medicine, Budapest, Hungary.

出版信息

Exp Clin Endocrinol. 1988 Aug;91(3):365-8. doi: 10.1055/s-0029-1210771.

DOI:10.1055/s-0029-1210771

PMID:3150834

Abstract

The cause of serum T4 elevation after iopanoic acid administration was searched in euthyroid subjects. 3 gr iopanoic acid was given per os to 9 healthy volunteers (group I), in other 5 volunteers a TRH test was performed prior to iopanoic acid administration (group II). In group I TSH, T4, FT4I and rT3 levels increased, in group II T3 and FT3I decreased, but no TSH, T4, FT4I increase was seen, obviously, because of the exhaustion of pituitary TSH content by TRH. On the ground of the findings T4 elevation caused by iopanoic acid is predominantly consequence of TSH release and not that of inhibited T4 conversion rate.

摘要

在甲状腺功能正常的受试者中探寻了服用碘番酸后血清T4升高的原因。给9名健康志愿者口服3克碘番酸（第一组），另外5名志愿者在服用碘番酸前进行了促甲状腺激素释放激素（TRH）试验（第二组）。第一组中促甲状腺激素（TSH）、T4、游离甲状腺素指数（FT4I）和反三碘甲状腺原氨酸（rT3）水平升高，第二组中T3和游离三碘甲状腺原氨酸指数（FT3I）降低，但未观察到TSH、T4、FT4I升高，显然，这是由于TRH使垂体TSH含量耗竭所致。基于这些发现，碘番酸引起的T4升高主要是TSH释放的结果，而非T4转化率受抑制的结果。