具有软、硬阳离子环的共聚物作为高度选择性的抗菌剂，以对抗抗药性微生物和生物膜。
Copolymers with both soft and rigid cationic rings as highly selective antimicrobials to combat antibiotic resistant microbes and biofilms.
机构信息
Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore.
出版信息
J Mater Chem B. 2019 Sep 25;7(37):5620-5625. doi: 10.1039/c9tb01264h.
PMID:31508648
Abstract
A new series of main-chain copolymers constructed by linkage of both soft and rigid cationic rings has been developed. The imidazolium-DABCO copolymers possess good biocompatibility, high antimicrobial efficacy and lower propensity to develop resistance against a broad range of microbes, including multidrug resistant strains, and their respective biofilms.
摘要
已开发出一系列通过软阳离子环和硬阳离子环连接构建的新型主链共聚物。该咪唑鎓-DABCO 共聚物具有良好的生物相容性、高效的抗菌性能和较低的耐药性倾向，对包括多药耐药株及其生物膜在内的多种微生物均有效。
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