Pradhan Sonali, Guddattu Vasudeva, Solomon Monica Charlotte
Manipal Academy of Higher Education, Manipal College of Dental Science, Department of Oral Pathology and Microbiology, Manipal, India.
Manipal Academy of Higher Education, School of Public Health, Department of Statistics, Prasanna, Manipal, India.
J Appl Oral Sci. 2019 Sep 9;27:e20180348. doi: 10.1590/1678-7757-2018-0348.
SOX2 is a transcription factor related to the maintenance of stem cells in a pluripotent state. Podoplanin is a type of transmembrane sialoglycoprotein, which plays an important role in tumor progression and metastasis. This study aims to determine association of SOX2 and podoplanin expression in the progression of oral squamous cell carcinomas and to elucidate the association between two proteins. Label="METHODOLOGY">The immunohistochemical expression of SOX2 and podoplanin were evaluated in 60 cases of primary oral squamous cell carcinomas. The correlation between the SOX2 and podoplanin expression and the clinicopathological features of the tumors and the patient outcomes were assessed. RESULTS The expression of SOX2 was seen in 38/60 (63%) of the cases and the expression for podoplanin was seen in 45/60 (75%) cases. There was a significant inverse correlation between the expression of SOX2 and podoplanin with the tumor grade (p=0.002 and p=0.017, respectively). There was a high expression of SOX2 in 9/13 cases that presented with disease free survival. Survival analysis showed that a high expression of SOX2 correlated positively (p=0.043) with the disease-free survival. There was a significant positive association between the pattern of SOX2 and podoplanin expression (p=0.002). CONCLUSION A high expression of SOX2 was associated with better disease-free survival. The expression of podoplanin was associated with the degree of differentiation of the tumors. Analysis of these biomarkers can aid in the prognosis and treatment of oral squamous cell carcinomas.
SOX2是一种与维持干细胞多能状态相关的转录因子。血小板内皮细胞黏附分子是一种跨膜唾液酸糖蛋白，在肿瘤进展和转移中起重要作用。本研究旨在确定SOX2和血小板内皮细胞黏附分子表达在口腔鳞状细胞癌进展中的相关性，并阐明这两种蛋白之间的关联。方法：对60例原发性口腔鳞状细胞癌患者进行SOX2和血小板内皮细胞黏附分子的免疫组化表达评估。评估SOX2和血小板内皮细胞黏附分子表达与肿瘤临床病理特征及患者预后之间的相关性。结果：60例病例中，38例（63%）可见SOX2表达，45例（75%）可见血小板内皮细胞黏附分子表达。SOX2和血小板内皮细胞黏附分子的表达与肿瘤分级之间存在显著负相关（分别为p = 0.002和p = 0.017）。13例无病生存的病例中有9例SOX2高表达。生存分析显示，SOX2高表达与无病生存呈正相关（p = 0.043）。SOX2和血小板内皮细胞黏附分子的表达模式之间存在显著正相关（p = 0.002）。结论：SOX2高表达与较好的无病生存相关。血小板内皮细胞黏附分子的表达与肿瘤的分化程度相关。分析这些生物标志物有助于口腔鳞状细胞癌的预后评估和治疗。
