Attramadal Cecilie G, Halstensen Trond S, Dhakal Hari P, Ulekleiv Camilla H, Boysen Morten E, Nesland Jahn M, Bryne Magne
Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
Department of Pathology, Oslo University Hospital, The Norwegian Radium Hospital, Faculty of Medicine, University of Oslo, Oslo, Norway.
J Oral Pathol Med. 2015 Aug;44(7):515-22. doi: 10.1111/jop.12261. Epub 2014 Sep 15.
Expression of the stem cell transcription factor SOX2 is often used to imply stemness and poor prognosis in cancer. However, its role in oral squamous cell carcinoma (OSCC) is not fully elucidated.
Tumour tissues from 62 patients with primary, node negative and non-metastatic OSCCs were used to evaluate SOX2 expression by immunohistochemistry. The results were correlated to clinicopathology, treatment and disease recurrences.
The majority of the OSCCs (88%) expressed SOX2. Patients with higher nuclear SOX2 staining intensity in the invasive front compared to the adjacent normal epithelium, had a remarkable longer disease-free period if they received adjuvant post-operative radiotherapy (P = 0.001). This was in particular evident for highly differentiated OSCCs, as none of the high SOX2-expressing tumours reoccurred in contrast to all low SOX2-expressing OSCCs.
High nuclear SOX2 expression in the invasive front was associated with dramatic longer disease-free period than low SOX2-expressing carcinomas after post-operative radiotherapy in small OSCCs. The result suggested that high nuclear SOX2 expression at the invasive front may predict radiosensitivity.
干细胞转录因子SOX2的表达常被用于暗示癌症中的干性及不良预后。然而，其在口腔鳞状细胞癌（OSCC）中的作用尚未完全阐明。
选取62例原发性、无淋巴结转移及非转移性OSCC患者的肿瘤组织，采用免疫组织化学法评估SOX2表达。结果与临床病理、治疗及疾病复发情况相关。
大多数OSCC（88%）表达SOX2。与相邻正常上皮相比，侵袭前沿核SOX2染色强度较高的患者，若接受术后辅助放疗，其无病生存期显著延长（P = 0.001）。这在高分化OSCC中尤为明显，因为与所有低SOX2表达的OSCC相比，高SOX2表达的肿瘤均未复发。
在小的OSCC中，侵袭前沿高核SOX2表达与术后放疗后低SOX2表达的癌相比，无病生存期显著延长。结果表明，侵袭前沿高核SOX2表达可能预测放射敏感性。
