Institute of Biosciences, Life Sciences Center, Vilnius University, Vilnius, Lithuania.
Institute of Biosciences, Life Sciences Center, Vilnius University, Vilnius, Lithuania.
Biol Psychol. 2019 Nov;148:107767. doi: 10.1016/j.biopsycho.2019.107767. Epub 2019 Sep 8.
Indications exist that use of oral contraceptives affects women's socio-emotional behaviour, brain function and, cognitive abilities, but the information is still scarce and ambiguous. We aimed to examine affective processing of visual stimuli between oral contraceptive users (OC, n = 33) and naturally cycling women (NC, n = 37) using the event-related potential (ERP) method. The main findings are: (i) emotionally arousing stimuli elicited significantly enlarged late positive potential (LPP) amplitudes compared to neutral stimuli, (ii) anti-androgenic OC users demonstrated diminished brain reactivity to visual stimuli, and (iii) significantly blunted reaction to highly unpleasant images. In addition, a positive relationship between GFP evoked by the highly unpleasant and highly pleasant visual emotional stimuli and progesterone was observed in NC women, while OC users demonstrated a trend of negative relationship between GFP and progesterone level. These findings suggest possible modulations of affective processing of visual stimuli when hormonal contraceptives are used.
有迹象表明，口服避孕药会影响女性的社会情感行为、大脑功能和认知能力，但相关信息仍然有限且模棱两可。我们旨在使用事件相关电位 (ERP) 方法，在口服避孕药使用者 (OC，n=33) 和自然周期女性 (NC，n=37) 之间检查视觉刺激的情感处理。主要发现包括：(i) 与中性刺激相比，情绪刺激诱发的晚正电位 (LPP) 幅度明显增大，(ii) 抗雄激素 OC 使用者对视觉刺激的大脑反应减弱，以及 (iii) 对高度不愉快的图像的反应明显迟钝。此外，在 NC 女性中观察到高度不愉快和高度愉快的视觉情绪刺激诱发的 GFP 与孕激素之间呈正相关，而 OC 使用者表现出 GFP 与孕激素水平之间呈负相关的趋势。这些发现表明，当使用激素避孕药时，视觉刺激的情感处理可能会发生调节。
